Severe Obesity Associated With Pituitary Corticotroph Hyperplasia and Neoplasia
Authors' conclusion
Our data indicate an association between CH/neoplasia and obesity. It remains unclear whether obesity is the cause or effect of adrenocorticotropic hormone and cortisol excess.
Study context
- Population
- Adult autopsies; pituitary and adrenal glands reviewed
- Participants
- 161 adult autopsies
- Exposure
- Body mass index (BMI) categories
- Leann = 53reference
- Outcome
- Incidence of corticotroph hyperplasia (CH) or lymphocyte infiltration in the pituitary
Methodological detailssingle-institution, 2010–2019
- Single-institution
- 2010–2019
Main finding
As reported in the abstract
Pituitary CH/neoplasia
P < 0.0001
- Corticotroph hyperplasia (CH)/neoplasia identified in pituitary glands
- 44 of 161
Observational data: associations, not effects.
Further findings
Small corticotroph tumors
- Patients with small corticotroph tumors
- 15
- Lean patients with a tumor (associated with Crooke hyaline change of nontumorous corticotrophs)
- 1
Adrenal cortex
- CH and neoplasia associated with adrenal cortical hyperplasia and lipid depletion
Pituitary T and B lymphocyte infiltration
- Lymphocyte foci in every weight category; no independent association between BMI and lymphocyte inflammation
Original publication
Severe Obesity Associated With Pituitary Corticotroph Hyperplasia and Neoplasia. Endocr Pract. Published 31 March 2023. doi:10.
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