Initial pathology in aggressive pituitary tumours and carcinomas: 2b or not 2b?—that is the question
Authors' conclusion
The comparison of the high percentage (67.4%) of grade 2b tumours in this selected cohort of APT/PC with the low percentage (8.8%) in a surgical cohort of unselected tumours shows that the initial pathological diagnosis of grade 2b tumour may be considered, in the clinic, as representing a diagnosis of APT.
Study context
- Population
- Patients with aggressive pituitary tumours (APT) and pituitary carcinomas (PC) in whom the five-tiered clinicopathological classification could be applied43 tumours classifiable
- Participants
- 171 patients
- Outcome
- Grade 2b (invasive and proliferative) at initial surgery
- Follow-up
- Initial surgery
Main finding
As reported in the abstract
- Grade 2b tumours
- 29/43 (67.4%)
- Grade 2b that developed metastases during follow-up (PC, grade 3)
- 44.8%
- Grade 2b with Ki-67 ≥10% (grade 2b*)
- 55.1%
- Grade 2a (invasive and non-proliferative)
- 30.2 %
- Grade 1b* (non-invasive, highly proliferative) tumour that metastasised
- 1
- Sensitivity of grade 2b for diagnosis of APT at initial surgery
- 68%
- Specificity of grade 2b for diagnosis of APT at initial surgery
- 90%
- Grade 2b in a surgical cohort of unselected tumours
- 8.8%
Observational data: associations, not effects.
Original publication
Initial pathology in aggressive pituitary tumours and carcinomas: 2b or not 2b?—that is the question. Eur J Endocrinol. Published 23 March 2023. doi:10.
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