Mortality in Acromegaly Diagnosed in Older Individuals in Spain Is Higher in Women Compared to the General Spanish Population
Authors' conclusion
The mortality in patients with acromegaly diagnosed in older individuals was no different between both periods, and there was no overall SMR difference compared with the general Spanish population. However, the SMR was higher in women. As CVD is the leading cause of mortality, it seems advisable to initiate an intense CVD protective treatment as soon as acromegaly is diagnosed, particularly in women, in addition to tight acromegaly control to prevent excess mortality.
Study context
- Population
- Patients diagnosed with acromegaly at age 65 or older, Spanish tertiary care centers
- Participants
- 118 patients
- Exposure
- Diagnosis before vs after 2010; mortality vs general Spanish population
- Outcome
- Mortality vs general Spanish population (age- and sex-adjusted SMR)
Methodological detailsmulticentre, tertiary care centers
- Multicentre
- Tertiary care centers
Main finding
As reported in the abstract
Overall SMR
1.02
95% CI 0.57–1.54
SMR, men
0.60
95% CI 0.35–1.06
SMR, women
1.80
95% CI 1.07–2.94
Observational data: associations, not effects.
Further findings
Deaths
- Died, without differences between groups
- 29 (24.6%)
- Most common cause of death
- Cardiovascular disease (CVD)
Treatment and biochemical control
- No differences in first-line treatment or biochemical control between periods, except faster biochemical control after 2010
Original publication
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