Glucose metabolism outcomes after pituitary surgery in patients with acromegaly
Authors' conclusion
Glucose metabolism improved in patients with acromegaly after surgery and 21% of the diabetic patients experienced diabetes remission; being more frequent in patients of older age, and those who experienced surgical cure and those with preserved anterior pituitary function after surgery.
Study context
- Population
- Patients with acromegaly undergoing first transsphenoidal surgery at 33 tertiary Spanish hospitals (ACRO-SPAIN study)
- Participants
- 604 patients
- Outcome
- Remission of DM after pituitary surgery and its predictors
- Follow-up
- Last visit after surgery
Methodological detailsnational, multicenter, 33 tertiary Spanish hospitals, Median follow-up 91 months (IQR 45-163), Surgical remission of acromegaly evaluated by the 2000 and 2010 criteria
- National
- Multicenter
- 33 tertiary Spanish hospitals
- Median follow-up 91 months (IQR 45-163)
- Surgical remission of acromegaly evaluated by the 2000 and 2010 criteria
Main finding
As reported in the abstract
DM remission among DM patients
- Diabetes mellitus (DM) patients with diabetes remission
- 21.1%
- Of them, with surgical remission of acromegaly
- 56.7%
- Predictor of DM cure: older age, HR
- 1.77 (1.31 to 2.43) (95% CI)
- Predictor of DM cure: surgical cure achieved, HR
- 2.10 (1.01 to 4.37) (95% CI)
- Predictor of DM cure: anterior pituitary function not affected after surgery, HR
- 3.38 (1.17 to 9.75) (95% CI)
Observational data: associations, not effects.
Further findings
DM at acromegaly diagnosis
- Patients with DM
- 23.8%
- Median HbA1c (IQR)
- 6.9% (6.4-7.9) [51.9 mmol/mol (46.4-62.8)]
Factors associated with greater DM prevalence (multivariate analysis) · acromegaly diagnosis
- Older age, OR
- 1.02 (1.00-1.05) (95% CI)
- Dyslipidemia, OR
- 5.25 (2.81 to 9.79) (95% CI)
- Arthropathy, OR
- 1.39 (2.82 to 9.79) (95% CI)
- Higher IGF-1 levels, OR
- 1.30 (1.05 to 1.60) (95% CI)
- Arthropathy OR as printed lies outside its printed CI
Original publication
Glucose metabolism outcomes after pituitary surgery in patients with acromegaly. Pituitary. Published 28 June 2024. doi:10.
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