Pituitary apoplexy: a systematic review of non-gestational risk factors
Authors' conclusion
No single non-gestational risk factor is solely responsible for the development of PA in a pituitary adenoma compared to the control population. Tumor size (macroadenoma) and the non-functioning status of the adenoma are the only significant factors contributing independently toward an apoplectic event in most patients. Such patients can be prioritized for early pituitary tumor resection.
Study context
- Population
- Adult patients with pituitary adenoma
- Participants
- 4,937 patients7 studies
- Outcome
- Non-gestational risk factors associated with development of PA
Methodological detailsPRISMA guidelines, with case report
- PRISMA guidelines
- With case report
Pooled result
As reported in the abstract
Non-gestational risk factors for PA
- Pituitary Apoplexy (PA) (including subclinical PA (SPA) and clinical PA (CPA)) among included participants
- 490 (9.92%)
- Macroadenomas: significant risk factor consistently in multivariate analysis
- three retrospective studies
- Negative staining of the tumor: significant risk factor consistently in multivariate analysis
- two retrospective studies
Original publication
Pituitary apoplexy: a systematic review of non-gestational risk factors. Pituitary. Published 27 June 2024. doi:10.
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