Antiplatelet and anticoagulation therapy and the risk of pituitary apoplexy in pituitary adenoma patients
Authors' conclusion
Although pituitary tumors have a high risk for spontaneous hemorrhage, the use of aspirin is not a risk for hemorrhage. Our study did not find an increased risk of apoplexy with clopidogrel or anticoagulation, but further investigation is needed with a larger cohort. Confirming other reports, male sex is associated with an increased risk for PA.
Study context
- Population
- Pituitary adenoma patients, single center77 with pituitary apoplexy (PA) (23%)
- Participants
- 342 patients
- Exposure
- Pituitary adenoma patients with vs without PA
- Apoplexyn = 77
- Outcome
- Risk of PA in patients on antiplatelet/anticoagulation (AP/AC) therapy
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
AP/AC use in patients with vs without apoplexy
- No apoplexy vs Apoplexy: P = 0.5
- No apoplexy vs Apoplexy: P = 0.5
- No apoplexy vs Apoplexy: P = 0.7
Observational data: associations, not effects.
Further findings
| Outcome | Apoplexy | No apoplexy | P value |
|---|---|---|---|
| INRNon-clinical difference; predictor for apoplexy | 1.07 ± 0.15 | 1.01 ± 0.09 | P < 0.001 |
Predictors of apoplexy
- Male sex was a predictor for apoplexy
- P < 0.001
- Pre-operative hormone treatment was protective from apoplexy
- P < 0.001
Original publication
Antiplatelet and anticoagulation therapy and the risk of pituitary apoplexy in pituitary adenoma patients. Pituitary. Published 28 April 2023. doi:10.
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