Clinical characteristics of functioning gonadotroph adenoma in women presenting with ovarian hyperstimulation: Audit of UK pituitary centres
Authors' conclusion
FGA is a rare cause of spontaneous OHSS. TSS improves clinical and biochemical features of ovarian hyperstimulation in FGAs. Improved awareness of FGA will prevent inappropriate emergency ovarian surgery.
Study context
- Population
- Women diagnosed with functioning gonadotroph adenoma (FGA)-induced ovarian hyperstimulation syndrome (OHSS), specialist neuroendocrine centres in the UK
- Participants
- 7 FGA cases
- Outcome
- Clinical course of FGA-induced OHSS
Methodological detailsaudit of eight UK regional pituitary centres, multicentre
- Audit of eight UK regional pituitary centres
- Multicentre
Main finding
As reported in the abstract
- FGA cases in women, all causing OHSS
- 7
- Mean age at diagnosis
- 33.4 years
- Abdominal pain at presentation
- 100%
- Irregular periods at presentation
- 71%
- Headache at presentation
- 57%
- Visual disturbances at presentation
- 43%
- Ovarian surgery before FGA diagnosis
- 3 of 7
- Underwent transsphenoidal surgery (TSS)
- 6
- Incomplete tumour resection after TSS
- 5
Observational data: associations, not effects.
Original publication
Clinical characteristics of functioning gonadotroph adenoma in women presenting with ovarian hyperstimulation: Audit of UK pituitary centres. Clin Endocrinol (Oxf). Published 10 July 2023. doi:10.
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