Venous thromboembolism in patients with pituitary adenoma: UK multicentre cohort study
Authors' conclusion
Patients with CD exhibit a significantly elevated risk of VTE compared to those with acromegaly or NFPA, with diabetes mellitus independently associated with this risk. In CD, VTEs were more frequently diagnosed around the time of diagnosis and during the peri-operative period.
Study context
- Population
- Patients diagnosed with acromegaly, NFPA or Cushing's disease (CD) across 3 UK centres, 2010–2021
- Participants
- 827 patients
- Exposure
- CD vs NFPA vs acromegaly
- CDn = 107
- NFPAn = 502reference
- Acromegalyn = 218reference
- Outcome
- VTE risk (cumulative incidence)
Methodological detailsobservational, multicentre
- Observational
- Multicentre
Main finding
As reported in the abstract
Cumulative incidence of VTE
Odds ratio
21.05
P < 0.001
CD vs NFPA
Odds ratio
4.48
P = 0.002
CD vs Acromegaly
Observational data: associations, not effects.
Further findings
Factors associated with venous thromboembolism (VTE) (Cox regression)
- CD diagnosis, HR
- 46.87 (P < .001)
- History of diabetes or impaired glucose tolerance, HR
- 3.48 (P = .008)
Timing of VTE in CD
- VTEs recorded in CD
- 12
- Within 1 year of CD diagnosis
- 8/12
- Within 45 days post-transsphenoidal surgery
- 4
Follow-up time
- Similar across diagnostic groups, median ∼13.3-13.5 years
- P = 0.41
Original publication
Venous thromboembolism in patients with pituitary adenoma: UK multicentre cohort study. Eur J Endocrinol. Published 3 July 2025. doi:10.
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