Pituitary adenoma and intracerebral aneurysms: case series, systematic review and meta-analysis
Authors' conclusion
Patients with PAs show a higher IAs prevalence compared with the general population, likely reflecting combined hemodynamic, anatomical, and endocrine influences.
Study context
- Population
- Patients with coexisting intracranial aneurysms (IAs) and pituitary adenoma (PA); PubMed and Embase searched up to December 15, 202571 studies
- Participants
- 74 vs 5,264
- Comparison
- Group 1 vs Group 2
- Group 1n = 74
- Group 2n = 5,264
- Outcome
- Prevalence of IAs in PA patients
Methodological detailsPRISMA 2020, individual patient-level data and aggregate prevalence data analysed separately, Most studies have a low risk of bias (RoB) (Joanna Briggs Institute tools)
- PRISMA 2020
- Individual patient-level data and aggregate prevalence data analysed separately
- Most studies have a low RoB (Joanna Briggs Institute tools)
Pooled result
As reported in the abstract
Pooled prevalence of IAs among PAs
Group 2
4%
CI 2–4%
- Heterogeneity
- I² = 92.1%, τ² = 1.1050, p < 0.0001
Further pooled results
Sex-stratified IA prevalence (Group 2)
- Females
- 8% (95% CI: 6%-9%)
- Males
- 6% (95% CI: 4%-7%)
- Sex-specific IA prevalence significantly higher in male and female PA patients vs general population
- P < 0.01
Clinical features (Group 1)
- Macroadenomas
- 91.9%
- Non-functioning PAs
- 40.5%
- IAs in cavernous segment of internal carotid artery
- 33%
- IA diagnosis significantly later than PA diagnosis
- P < 0.01
Original publication
Pituitary adenoma and intracerebral aneurysms: case series, systematic review and meta-analysis. Pituitary. Published 16 May 2026. doi:10.
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