Prevalence and evolution of hypertension in a large Iberian cohort of patients with acromegaly
Authors' conclusion
At the time of acromegaly diagnosis up to 50% of patients have hypertension, and around 15% of them experience hypertension remission after pituitary surgery. The probability of remission is higher in patients with milder baseline hypertension and higher IGF-1 levels and in those achieving a greater postoperative decrease of GH and IGF-1.
Study context
- Population
- Patients with acromegaly surveilled at 25 tertiary hospitals in Spain and Portugal
- Participants
- 434 patients
- Exposure
- Patients with vs without hypertension at acromegaly diagnosis
- Hypertensionn = 209
- No hypertensionn = 225reference
- Outcome
- Prevalence of hypertension at acromegaly diagnosis
- Follow-up
- Acromegaly diagnosis
Methodological detailsmulticenter, 25 tertiary hospitals
- Multicenter
- 25 tertiary hospitals
Main finding
As reported in the abstract
Prevalence of hypertension
209
48.2%
Observational data: associations, not effects.
Further findings
Blood pressure (BP) change 3 months after pituitary surgery
- ΔSBP
- - 5.0mmHg (95%CI −2.37 to −7.61)
- ΔDBP
- - 2.2mmHg (95% CI −0.66 to −3.75)
Incident hypertension in initially normotensive patients · median follow-up 8.4 years [IQR 4.8-12.8]
- Developed hypertension
- 16% (n = 35/218)
Hypertension remission in hypertensive patients · median follow-up 8.4 years [IQR 4.8-12.8]
- Achieved hypertension remission
- 14.1% (n = 27/192)
- Remission more likely with fewer antihypertensive drugs and higher IGF-1 at diagnosis, and greater postoperative decrease in GH and IGF-1
Original publication
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