IGF-1 is positively associated with BMI in patients with acromegaly
Authors' conclusion
In contrast to individuals without acromegaly, BMI is significantly and positively associated with IGF-1 in acromegaly across the weight spectrum. Future studies are needed to determine if obese patients with acromegaly experience more significant symptoms related to their disease, or if patients with a low BMI may require different diagnostic criteria.
Study context
- Population
- Patients who underwent resection of a pituitary adenoma at a large academic medical center, 1/1/2015–5/31/2021
- Participants
- 197 patients
- Exposure
- Acromegaly vs NFPA
- Acromegalyn = 32
- NFPAn = 165reference
- Outcome
- Association between BMI and %ULN IGF-1
Methodological detailssingle academic medical center
- Single academic medical center
Main finding
As reported in the abstract
- Acromegaly: significant positive association between BMI and %ULN IGF-1 (p < 0.05)
- R = 0.35
- NFPA overall: no association between BMI and %ULN IGF-1
- p = 0.22
Observational data: associations, not effects.
Further findings
| Outcome | Acromegaly | NFPA | P value |
|---|---|---|---|
| %ULN IGF-1 | 228.2% (interval [159.0, 271.4]) | 32.2% (interval [18.5, 50]) | P < 0.0001 |
- BMI in acromegaly
- 30.8 · Median · range 20.9–42.6 · kg/m²
Association between BMI and %ULN IGF-1 in NFPA with BMI ≥ 35 kg/m²
- Significant inverse association (p = 0.02)
- rho = - 0.39
Original publication
IGF-1 is positively associated with BMI in patients with acromegaly. Pituitary. Published 17 March 2023. doi:10.
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