Circadian rhythm proteins as potential biomarkers in pituitary adenomas: an immunohistochemical analysis
Authors' conclusion
Alterations in the protein expression levels of circadian clock genes may contribute to the development and behavior of PAs.
Study context
- Population
- Patients with PA under follow-up at a pituitary center who underwent transsphenoidal surgery (TSS) between 8:00 AM and 2:00 PM; excluded: depression, psychiatric medication or melatonin agonists, preoperative night shifts
- Participants
- 86 vs 17
- Comparison
- Pituitary adenoma tissue vs adjacent non-neoplastic adenohypophysis
- Pituitary adenomas (PAs)n = 86
- Controln = 17reference
- Outcome
- Protein expression of circadian clock genes (BMAL1, CLOCK, CRY1, CRY2, PER2)
Main finding
As reported in the abstract
- PAs vs Control: P = 0.064
- PAs vs Control: P = 0.053
Further findings
| Outcome | Recurrent | No recurrence | P value |
|---|---|---|---|
| Total CLOCK score by recurrenceLower with recurrence | 225 (range or IQR 165–270) | 250 (range or IQR 212.5–280) | P = 0.038 |
Preoperative maximum tumor size vs total CRY2 score
- Negative correlation, r
- −0.463, p < 0.001
PA subtypes
- CRY2 showed the most prominent differences among PA subtypes
Original publication
Circadian rhythm proteins as potential biomarkers in pituitary adenomas: an immunohistochemical analysis. Pituitary. Published 9 December 2025. doi:10.
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