An endocrinological point of view on a large series of pituitary stalk lesions
Authors' conclusion
In conclusion, we describe a unique series of PSL that contribute to the understanding of the heterogeneous spectrum of PSL. In this study, we discuss the clinical and radiological features of PSL and provide current recommendations for differential diagnosis.
Study context
- Population
- Adults with pituitary stalk abnormalities (59 F/39 M; median age 37 years)
- Participants
- 98 adults
- Outcome
- PS lesion types
Main finding
As reported in the abstract
- Pituitary stalk (PS) thickening
- 52%
- PS thinning
- 18.4%
- PS nodularity
- 17.3%
- Distribution of lesion types varied across etiological categories
- p < 0.001
Observational data: associations, not effects.
Further findings
Arginine vasopressin deficiency (AVP-D)
- AVP-D rates in non-adenomatous local neoplastic lesions, inflammatory etiologies and solid organ metastases
- 57% to 61%
Isolated PS involvement
- Most often due to Langerhans cell histiocytosis
- 25%
Other clinical features by etiology
- Solid organ metastases occurred in older patients; PS thickening more pronounced and extrapituitary involvement highest in solid organ metastases
- Congenital cases mainly had growth retardation and gonadal dysfunction
- In PSIS, all had ectopic neurohypophysis, lacked AVP-D, and showed ≥1 anterior pituitary hormone deficiency
Original publication
An endocrinological point of view on a large series of pituitary stalk lesions. Pituitary. Published 9 December 2025. doi:10.
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