Cerebrospinal Fluid Metabolomic Pattern of Different Pituitary Stalk Lesions
Authors' conclusion
Our study is the first to systematically investigate the metabolomics of CSF in different pituitary stalk lesions. CSF metabolomics is a useful strategy for biomarker discovery.
Study context
- Population
- Patients with different pituitary stalk lesions treated at Peking Union Medical College Hospital
- Participants
- 27 / 10 / 10
- Comparison
- Cerebrospinal fluid (CSF) metabolome across germ cell tumor (GCT), hypophysitis and Langerhans cell histiocytosis (LCH) + Erdheim-Chester disease (ECD)
- GCTn = 27
- Hypophysitisn = 10
- LCH + ECDn = 10
- Outcome
- CSF metabolomic pattern (liquid chromatography-mass spectrometry (LC-MS))
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Metabolites significantly differing, GCT vs hypophysitis (P < .05)
- 44
- Differential metabolites, GCT with CSF β-hCG < 5 mIU/mL vs hypophysitis (P < .05, fold change > 1.5 or < 1/1.5); all with AUC above 0.7
- 15
- Metabolites significantly differing, GCT vs LCH + ECD (P < .05)
- 9
- Metabolites significantly differing, GCT (CSF β-hCG < 5 mIU/mL) vs LCH + ECD (P < .05, fold change > 1.5 or < 1/1.5)
- 7
- Metabolites significantly differing, hypophysitis vs LCH + ECD (P < .05)
- 6
- Of these, fold change more than 1.5 or less than 1/1.5
- 5
Further findings
Metabolites associated with clinical test results
- Associated with clinical test results (ρ > 0.2, P < .05)
- 67
- Strong correlation (ρ > 0.4, P < .05)
- 29
Original publication
Cerebrospinal Fluid Metabolomic Pattern of Different Pituitary Stalk Lesions. J Clin Endocrinol Metab. Published 28 September 2023. doi:10.
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