Clinical and prognostic significance of granulation patterns in somatotroph adenomas/tumors of the pituitary: a meta-analysis
Pooled result · Postoperative endocrinological remissionResult — go to the resultOR for endocrinological remission 0.60 95% CI 0.40–0.90Authors' conclusion
SGST and DGST were demographically, clinicopathologically, and molecularly different from each other with the former associated with adverse treatment outcomes and poor response to medical therapy. There are still gaps in translational studies that could help us better understand the behavior of these tumors and identify potential targets in the treatment of sparsely granulated tumors.
Study context
- Population
- Somatotroph adenomas/tumors of the pituitary; studies from two electronic databases
- Comparison
- Sparsely granulated vs densely granulated somatotroph adenoma/tumor
- Outcome
- Postoperative endocrinological remission
- Follow-up
- Postoperative
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
OR for endocrinological remission
0.60
95% CI 0.40–0.90
P = 0.01
SGSTvs DGST
OR for endocrinological remission 0.60 (95% CI 0.40–0.90); P = 0.01
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Response to SRL · postoperative follow-upPoorer response with SGST | 0.16 (0.08–0.35) | P < 0.001 | |
| Prevalence of GSP mutations | 0.36 (0.17–0.79) | P = 0.01 | |
| 0.050.21520Odds ratio (log scale) |
Demographics
- SGST associated with younger age and lower male-to-female ratio vs DGST
- P < 0.001
Tumor size and extension
- SGST had larger tumor size and higher rate of cavernous sinus and suprasellar extension vs DGST
- P < 0.001
Original publication
Clinical and prognostic significance of granulation patterns in somatotroph adenomas/tumors of the pituitary: a meta-analysis. Pituitary. Published 21 September 2023. doi:10.
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