Impact of granulation pattern on surgical and long-term outcomes in Cushing’s disease: a comparative study of DGCT and SGCT
Authors' conclusion
Despite similar preoperative and intraoperative characteristics, SGCT was associated with a higher recurrence rate and more aggressive biological behavior.
Study context
- Population
- Patients with CD who underwent TSS between 2004 and 2024
- Participants
- 208 patients
- Exposure
- DGCT vs SGCT
- DGCTn = 175
- SGCTn = 33reference
- Outcome
- Early remission
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Long-term recurrence
Preoperative tumor characteristics and surgical approaches
- No significant differences between DGCT and SGCT
Interval from symptom onset to surgery
- Shorter interval in SGCT
Histopathology
- Higher MIB-1 indices and p53 expression in SGCT, indicating a more aggressive tumor phenotype
Original publication
Impact of granulation pattern on surgical and long-term outcomes in Cushing’s disease: a comparative study of DGCT and SGCT. Pituitary. Published 20 April 2026. doi:10.
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