Histopathological and radiological predictors of surgical remission failure in GH-secreting pituitary adenomas
Authors' conclusion
T2 signal intensity helps identify granulation patterns, but it does not predict surgical remission. Surgical remission failure is associated with cavernous sinus invasion and infrasellar extension greater than 4.93 mm, indicating more aggressive GH-secreting pituitary adenomas.
Study context
- Population
- GH-secreting pituitary adenomas assessed for granulation pattern, tumor volume, normalized T2 signal intensity, extrasellar extension and proliferative status
- Participants
- 107 adenomas
- Exposure
- Surgical remission vs non-remission at 6 months; densely (DG) vs sparsely granulated (SG) adenomas
- DGn = 52
- SGn = 55
- Outcome
- Radiological and histological predictors of surgical remission failure
- Follow-up
- 6 months post-surgery
Main finding
As reported in the abstract
Infrasellar extension predictive of remission failure, OR
1.186
p = 0.005
Cavernous sinus invasiveness predictive of remission failure, OR
2.997
p = 0.023
Infrasellar growth cutoff >4.93 mm for remission failure: sensitivity 58%, specificity 71%, AUC
0.67
p < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Surgical remission rate, SG vs DG · 6 months post-surgeryNo significant difference | P = 0.098 |
Granulation pattern and T2 signal intensity
- T2 signal intensity distinguished DG and SG subtypes
- Infrasellar extension more common than suprasellar or parasellar extension in both subtypes
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →