Impact of sex on mortality in patients with pituitary adenomas
Authors' conclusion
Though there seems to be a sex impact on mortality rates in pituitary adenomas, most data are conflicting.
Study context
- Population
- Patients with pituitary adenomas (acromegaly, Cushing’s disease (CD), prolactinomas, non-functioning pituitary adenomas (NFPA))
- Comparison
- Women vs men
- Outcome
- Sex differences in mortality
Methodological detailsPubMed, English-language studies published 1970–2025
- PubMed
- English-language studies published 1970–2025
Main finding
As reported in the abstract
- Several studies contradictory, most likely related to methodological variability
- Acromegaly: general trend of higher mortality in women vs men, particularly in newer studies
- CD: inconsistent results on sex differences; excess mortality observed in men
- Prolactinomas: mortality not well studied; studies on sex differences lacking
- NFPA: women also seem to have excess mortality
- Factors explaining sex differences not clear for any pituitary adenoma type
Original publication
Impact of sex on mortality in patients with pituitary adenomas. Pituitary. Published 6 February 2026. doi:10.
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