Pediatric and Adult Craniopharyngioma: A 37‐Year Experience at a National Referral Center
Authors' conclusion
CP carries a high risk of recurrence and neuroendocrine complications. This study, based on 37 years of experience in a reference center, is the first national report on CP patients, with findings consistent with previous literature. The management of these patients is complex and demands a highly experienced multidisciplinary team to achieve optimal long-term outcomes.
Study context
- Population
- Pediatric and adult craniopharyngioma (CP) patients aged 1–68 years, specialized referral center in Chile, 1986 to 2023
- Participants
- 87 participants
- Exposure
- Childhood vs Adulthood
- Childhoodn = 65
- Adulthoodn = 22
- Outcome
- Pituitary dysfunction and recurrence in CP
Methodological detailssingle referral center, stratified by age at onset
- Single referral center
- Stratified by age at onset
Main finding
As reported in the abstract
- ≥1 pituitary dysfunction at diagnosis
- 54%
- Thyrotropic dysfunction at diagnosis
- 28.2%
- Somatotropic dysfunction at diagnosis
- 27.9%
- Pituitary dysfunction after initial treatment
- 71%
- Thyrotropic dysfunction after initial treatment
- 59%
- Corticotropic dysfunction after initial treatment
- 48%
- Anterior panhypopituitarism
- 25%
- Permanent AVP deficiency
- 32%
- Tumor recurrence or progression
- 63%
Observational data: associations, not effects.
Further findings
Histology
- Adamantinomatous
- 84%
- Papillary
- 3%
- Unspecified
- 13%
Symptoms at presentation
- Headache
- 77%
- Visual disturbances
- 60%
- Nausea
- 45%
Original publication
Pediatric and Adult Craniopharyngioma: A 37‐Year Experience at a National Referral Center. Clin Endocrinol (Oxf). Published 30 January 2026. doi:10.
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