Reappraisal of colorectal polyps in acromegaly: study on prevalence, recurrence and risk factors
Authors' conclusion
Polyps’ recurrence and new onset are more frequent in patients with uncontrolled acromegaly, glucose metabolism impairment, and MS.
Study context
- Population
- Patients with acromegaly diagnosed 2000–2022 at “Federico II” University who underwent at least one colonoscopy
- Participants
- 171 patients
- Exposure
- Colonoscopy at diagnosis vs after diagnosis
- At diagnosisn = 120
- After diagnosisn = 51
- Outcome
- Colorectal polyp prevalence and recurrence risk factors
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Polyp prevalence
P = 0.975
Observational data: associations, not effects.
Further findings
Factors associated with polyps at diagnosis
- Polyps more frequent in older patients
- P = 0.003
- Polyps more frequent in diabetic patients
- P = 0.01
- Polyps more frequent with higher number of systemic complications
- P < 0.001
- Higher prevalence with presumed disease onset >6 years (median)
- P = 0.04
Factors higher in patients with vs without polyps (colonoscopy after diagnosis)
- Age at diagnosis
- P = 0.005
- Fasting glucose
- P < 0.001
- HbA1c
- P < 0.001
- HOMA-IR
- P = 0.009
- Number of systemic complications
- P = 0.004
Polyp recurrence at last evaluation · 10-years median colonoscopy follow-up
- Patients with multiple evaluations
- 49 (34.2%)
- Recurrence
- 38.2%
- Associated with uncontrolled acromegaly
- P = 0.003
- Associated with glucose metabolism impairment
- P = 0.031
- Associated with metabolic syndrome
- P = 0.004
- Fold higher recurrence risk with uncontrolled acromegaly
- 9.6
New-onset polyps at last evaluation after first negative colonoscopy
- New onset
- 24.2%
- Associated with male sex
- P = 0.006
- Associated with uncontrolled acromegaly
- P = 0.007
- Associated with metabolic syndrome
- P = 0.002
- Fold higher new-onset risk with uncontrolled acromegaly
- 11.5
Colon cancer
- Colon cancer overall
- 6 (3.5%)
Original publication
Reappraisal of colorectal polyps in acromegaly: study on prevalence, recurrence and risk factors. Pituitary. Published 19 January 2026. doi:10.
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