Prevalence and risk factors of colon polyps and other colonic lesions in acromegaly: Insights from colonoscopy screening
Authors' conclusion
Patients with acromegaly exhibited a higher prevalence of colon polyps, predominantly located in the distal colon, which typically displayed a single histopathological subtype. No increased rates of colonic dysplasia, colon cancer, or other colonic lesions were observed in patients with acromegaly, except for an elevated prevalence of anal fissures.
Study context
- Population
- Acromegaly patients and controls undergoing colonoscopy screening
- Participants
- 192 vs 256
- Comparison
- Acromegaly patients vs controls
- Acromegalyn = 192
- Controlsn = 256reference
- Outcome
- Prevalence of colon polyps
Main finding
As reported in the abstract
- Acromegaly vs Controls: P = 0.003
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Multiple polyp locationsMore frequent in Controls | P = 0.042 |
| Multiple histopathological subtypesMore frequent in Controls | P = 0.018 |
| Anal fissuresMore common with Acromegaly | P = 0.001 |
| DiverticulosisLess frequent with Acromegaly | P < 0.001 |
Number, size and histopathological subtypes of polyps
- No differences between groups
Polyp location in acromegaly
- Predominantly distal colon and rectum
Low-grade dysplasia, high-grade dysplasia and malignancy
- Similar between groups
Predictors of colon polyps in acromegaly
- Logistic regression identified no significant clinical or laboratory predictors
Original publication
Prevalence and risk factors of colon polyps and other colonic lesions in acromegaly: Insights from colonoscopy screening. Pituitary. Published 1 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →