Age-related differences in the clinical features and management of pituitary apoplexy: a cohort study
Authors' conclusion
PA management and outcomes were comparable in younger and older patients, despite greater comorbidities and more severe symptoms in older individuals. Histopathological findings suggest potential age-related differences in tumor biology, warranting further research. MRI would be preferred for diagnosis, particularly in older patients, as ischemic necrotic PA may be undiagnosed without advanced imaging.
Study context
- Population
- Patients with pituitary apoplexy (PA), Spanish multicenter cohort, 2010–2023
- Participants
- 301 patients18 Spanish hospitals
- Exposure
- PA patients aged ≥65 vs <65 years
- ≥65 yearsn = 116
- <65 yearsn = 185reference
- Outcome
- Treatment approach and outcomes by age group
Methodological detailsmulticenter, 18 Spanish hospitals
- Multicenter
- 18 Spanish hospitals
Main finding
As reported in the abstract
Conservative treatment rate, younger vs older
29.9 younger vs. 32.8% older
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Cranial nerve palsyHigher frequency in older patients | P = 0.02 |
| Necrosis on histopathologyMore necrosis in patients aged ≥65 years | P = 0.04 |
Comorbidities
- Patients aged ≥65 years had more comorbidities vs younger patients
Clinical presentation, incl. PA Score and radiological findings
- No significant differences, except cranial nerve palsy
Surgical resection rates and outcomes incl. mortality
- Comparable across age groups
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →