Transsphenoidal Surgery for Pituitary Neuroendocrine Tumours (PiTNETs) in a Tertiary Hospital: Are There Differences Between Young and Elderly Patients?
Authors' conclusion
With experienced surgical and endocrinological care, transsphenoidal surgery for elderly patients with PiTNET is effective and safe.
Study context
- Population
- Adults undergoing transsphenoidal surgery for PiTNET in a tertiary hospital, 2018–2023
- Participants
- 124 adults
- Exposure
- Elderly vs younger patients undergoing transsphenoidal surgery
- Elderlyn = 32
- Outcome
- Hormonal excess
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Hypopituitarism · higher with Elderly
P < 0.001
Macroadenomas · higher with Elderly
P = 0.002
Ki67 · lower with Elderly
P = 0.045
Median
| Outcome | Elderly | Younger | P value |
|---|---|---|---|
| Number of affected axesGreater with Elderly | 3 | 1 | P < 0.001 |
- ACTH excess
- P = 0.003
ACTH excess
- Only the rate of ACTH excess differed between groups
Most common surgical indication
- Elderly: visual impairment
- 31.3%
- Younger: functionality
- 42.4%, p = 0.012
Knosp grade
- No differences in Knosp grade
Tumour resection rate, visual improvement, hormonal status · 6-12 months
- No differences in tumour resection rate, visual improvement or hormonal status
Safety
Immediate postsurgical complications and hospital stay · immediate postsurgical period
- No differences in surgical or hormonal complications or hospital stay
Original publication
Transsphenoidal Surgery for Pituitary Neuroendocrine Tumours (PiTNETs) in a Tertiary Hospital: Are There Differences Between Young and Elderly Patients? Clin Endocrinol (Oxf). Published 24 March 2025. doi:10.
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