Thyroid Diseases in Patients With Pituitary Neuroendocrine Tumours
Authors' conclusion
Increased thyroid volume, goiter and multiple nodules are prevalent in GH-PitNETs patients, while autoimmune thyroiditis predominates in PRL-PitNETs. Treatment of PitNETs alleviates these thyroid manifestations. Routine thyroid ultrasound monitoring is recommended for PitNETs patients.
Study context
- Population
- Patients with pituitary neuroendocrine tumours (PitNETs) who underwent thyroid US, pituitary tests and thyroid function tests before and 1 year after treatment
- Participants
- 168 patients
- Exposure
- Thyroid disease across PitNET subtypes (GH vs PRL vs NF) and before vs 1 year after PitNET treatment
- GHn = 53
- PRLn = 65
- NFn = 50
- Outcome
- Thyroid characteristics by PitNET subtype
- Follow-up
- Before treatment
Main finding
As reported in the abstract
| Group | Value | Goitre incidence | Nodule incidence | Multiple nodules proportion | Autoimmune thyroiditis | TPOAb | TGAb |
|---|---|---|---|---|---|---|---|
| GH | 30.78 ± 7.87 mL | 73.58% | 54.17% | 79.31% | |||
| PRL | 18.46% | 169.63 ± 325.28 IU/mL | 236.23 ± 379.91 IU/mL |
Value
GH30.78 ± 7.87 mL
PRL— not stated in the abstract
Goitre incidence
GH73.58%
PRL— not stated in the abstract
Nodule incidence
GH54.17%
PRL— not stated in the abstract
Multiple nodules proportion
GH79.31%
PRL— not stated in the abstract
Autoimmune thyroiditis
GH— not stated in the abstract
PRL18.46%
TPOAb
GH— not stated in the abstract
PRL169.63 ± 325.28 IU/mL
TGAb
GH— not stated in the abstract
PRL236.23 ± 379.91 IU/mL
- Thyroid volume significantly larger in GH
- P < 0.01
- Goitre incidence higher in GH
- P < 0.01
- Nodule incidence higher in GH
- P < 0.01
- Multiple nodules proportion higher in GH
- P < 0.01
- Autoimmune thyroiditis more common in PRL
- P = 0.04
- Elevated TPOAb in PRL
- P = 0.02
- Elevated TGAb in PRL
- P = 0.02
Observational data: associations, not effects.
Further findings
Thyroid volume, before vs after treatment · 1 year postoperative
- Thyroid volume decreased from 23.45 ± 8.99 mL to 20.42 ± 6.48 mL
- P < 0.01
Thyroid goitre incidence, before vs after treatment · 1 year postoperative
- Goitre incidence decreased from 36.90% to 13.10%
- P < 0.01
TPOAb and TGAb in autoimmune thyroiditis, before vs after treatment · 1 year after treatment
- TPOAb decreased significantly
- P = 0.01
- TGAb decreased significantly
- P < 0.01
Original publication
Thyroid Diseases in Patients With Pituitary Neuroendocrine Tumours. Clin Endocrinol (Oxf). Published 23 April 2025. doi:10.
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