Serum biomarkers of colonic polyps in patients with acromegaly: a meta-analysis and systematic review
Authors' conclusion
We present the first meta-analysis and systematic review of serum biomarkers in patients with acromegaly or colonic polyps. The prevalence of colonic lesion polyps, is associated with higher IGF-1 × ULN levels, higher insulin levels in acromegaly. Further research is required to confirm GH and serum soluble Klotho levels as biomarkers of colonic polyps. When IGF-1 × ULN, fasting insulin levels change in patients with acromegaly, the occurrence of colonic polyps should be monitored. Early detection may reduce the possibility of developing malignant colon neoplasms.
Study context
- Population
- Patients with acromegaly; studies on serum biomarkers of colonic polyps, PubMed, Embase, Cochrane Library, Medline and Chinese databases, January 1, 1966, to May 8, 20228 articles
- Comparison
- Acromegaly with vs without colonic polyps
- Outcome
- Serum biomarker levels (meta-analysis)
Methodological detailsMeta-analysis and systematic review conducted using Stata MP 14.0
- Meta-analysis and systematic review conducted using Stata MP 14.0
Pooled result
As reported in the abstract
Estimate (95% CI)P value
Colonic polypsvs No colonic polyps
SMD (IGF-1 × ULN) 0.23(0.03–0.42)
P < 0.05Colonic polypsvs No colonic polyps
SMD (fasting insulin) 0.95(0.11–1.8)
P < 0.05- Colonic polyps vs No colonic polyps
- SMD (growth hormone (GH)) - 0.25 (95% CI - 0.41 to - 0.08); P < 0.05
- Between Colonic polyps and No colonic polyps · did not differ significantly
- SMD (IGF-1) −0.03 (95% CI - 0.22 to 0.17); P > 0.05
- Between Colonic polyps and No colonic polyps · did not differ significantly
- SMD (FPG) 0.14 (95% CI - 0.23 to 0.52); P > 0.05
Further pooled results
Other serum biomarkers (systematic review)
- No significant differences in HbA1c, TSH, free thyroxine, FT4, T3, PRL, total cholesterol, HDL, LDL, fibrinogen, clathrate antigen, serum antigen 19-9 and α-fetoprotein levels, but serum Klotho levels
Original publication
Serum biomarkers of colonic polyps in patients with acromegaly: a meta-analysis and systematic review. Pituitary. Published 21 December 2022. doi:10.
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