A Genetic Assessment of Dopamine Agonist-Induced Impulse Control Disorder in Patients With Prolactinoma
Authors' conclusion
Our results show that multiple neurotransmission systems affect DA-induced ICD in patients with prolactinoma.
Study context
- Population
- Patients with prolactinoma receiving dopamine agonist (cabergoline) treatment
- Participants
- 72 patients
- Comparison
- Cabergoline-treated prolactinoma patients with vs without dopamine agonist (DA)-induced impulse control disorder (ICD)
- ICDn = 20
- Outcome
- Genotype frequencies of DRD1, DRD3, COMT, DDC, GRIN2B, TPH2, OPRK1, OPRM1, SLC6A4, SLC6A3, HTR2A polymorphisms
Main finding
As reported in the abstract
- OPRK1/rs702764, DRD3/rs6280, HTR2A/rs6313, SLC6A4/rs7224199, GRIN2B/rs7301328, TPH2/rs7305115, COMT/rs4680, DRD1/rs4532 polymorphisms significantly increased in DA-induced ICD
Original publication
A Genetic Assessment of Dopamine Agonist-Induced Impulse Control Disorder in Patients With Prolactinoma. J Clin Endocrinol Metab. Published 10 December 2022. doi:10.
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