Impact of pituitary adenoma histological subtype on remission and disease control in acromegaly
Authors' conclusion
Histological subtype was not significantly associated with remission or control of acromegaly. Although a trend toward lower remission rates was observed in SG adenomas, its clinical impact appears limited.
Study context
- Population
- Patients who underwent surgery for GH or GH-PRL adenomas without prior medical therapy, 2012–2022
- Participants
- 128 patients
- Exposure
- DG vs SG vs GH-PRL adenomas
- Outcome
- Acromegaly remission
- Follow-up
- 3 months and last
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
Remission · 3 months
P = 0.337
Observational data: associations, not effects.
Further findings
Remission at last follow-up · last follow-up (after 42 months) — DG vs GH-PRL, SG · not significantly different
P = 0.091
Disease control at last follow-up · last follow-up (after 42 months) — DG vs GH-PRL, SG · not significantly different
P = 0.115
Adenoma subtype distribution
- Adenoma subtype distribution — Pure GH adenomas
- 61%
- Characteristics, SG vs DG
- P = 0.006
- Characteristics, SG vs DG
- P = 0.022
- Characteristics, SG vs DG
- P = 0.032
- Characteristics, SG vs DG
- P < 0.001
- Characteristics of GH-PRL adenomas · GH-PRL vs DG
- P = 0.024
- Characteristics of GH-PRL adenomas · GH-PRL vs DG
- P = 0.017
- Characteristics of GH-PRL adenomas · GH-PRL vs SG
- P < 0.001
Original publication
Impact of pituitary adenoma histological subtype on remission and disease control in acromegaly. J Clin Endocrinol Metab. Published 21 April 2026. doi:10.
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