Quality of Life in Acromegaly: Results From the ACROFAST Study
Authors' conclusion
Biochemical control is associated with improved symptoms and appearance-related QoL.
Study context
- Population
- Patients with acromegaly in the ACROFAST study; assessments at baseline, 6 and 12 months
- Comparison
- Controlled vs uncontrolled patients
- Primary endpoint
- AcroQoL scores and symptom burden by PASQ
Primary result
As reported in the abstract
AcroQoL appearance sub-dimension · end of study
P = 0.04
Further findings
PASQ score · end of study
P = 0.01
PASQ over time (linear mixed-effects model) · baseline, 6 and 12 months
- Controlled: reduction over time, estimated marginal means
- 19, 14, 14
- Uncontrolled: scores remained stable
Sex subgroup
- Women had worse scores for both quality of life (QoL) and symptoms tests
- Severity of symptoms correlated with QoL
Original publication
Quality of Life in Acromegaly: Results From the ACROFAST Study. Endocr Pract. Published 11 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →