Cardiovascular morbidity and mortality in acromegaly-associated diabetes: a Swedish nationwide study
Main finding · Overall mortalityResult — go to the resultHazard ratio 1.18 95% CI 0.96–1.46Authors' conclusion
The risk of cardiovascular morbidity was increased in patients with ACRO-DM compared to T2DM.
Study context
- Population
- Patients with acromegaly-associated diabetes and matched T2D controls, Swedish national registersmatched cohort
- Participants
- 348 vs 3,480
- Exposure
- Acromegaly-associated diabetes vs T2D
- ACRO-DMn = 348
- T2DMn = 3,480reference
- Outcome
- Overall mortality
Methodological detailsnationwide, matched cohort, matched 10:1 for sex, age, calendar year, diabetes duration
- Nationwide
- Matched cohort
- Matched 10:1 for sex, age, calendar year, diabetes duration
Main finding
As reported in the abstract
Hazard ratio
1.18
95% CI 0.96–1.46
ACRO-DMvs T2DM
HR 1.18 (95% CI 0.96–1.46)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Cardiovascular morbidity | 1.55 (1.24–1.94) | |
| Cardiovascular mortality | 1.12 (0.78–1.60) | |
| 0.512Hazard ratio (log scale) |
Baseline age
Baseline diabetes duration
Baseline cardiovascular morbidity
Hypertension
Heart failure
Arrhythmia
Stroke
Cardiovascular morbidity
- Increased hazards for VTE, specifically pulmonary, and arrhythmia in ACRO-DM
Original publication
Cardiovascular morbidity and mortality in acromegaly-associated diabetes: a Swedish nationwide study. J Clin Endocrinol Metab. Published 10 August 2026. doi:10.
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