Clinical Profile, Biochemical Characteristics, and Surgical Outcomes in Cushing Disease: An Age‐Stratified Analysis of a Large Tertiary‐Care Cohort
Authors' conclusion
This large single-center cohort demonstrates substantial recorded clinical and cardiometabolic burden at tertiary-care assessment in Cushing disease. Exploratory age-stratified patterns were observed in clinical phenotype and cortisol profile, while numerically similar early remission proportions were observed across tumor-size categories in descriptive analyses.
Study context
- Population
- Patients with confirmed CD managed at a high-volume tertiary-care centre, 2006–2025
- Participants
- 277 patients
- Outcome
- Clinical profile of CD
Methodological detailsretrospective observational audit, single-centre, tertiary-care, age-stratified analysis
- Retrospective observational audit
- Single-centre
- Tertiary-care
- Age-stratified analysis
Main finding
As reported in the abstract
- Female
- 71.8%
- Weight gain
- 79.4%
- Centripetal obesity
- 62.5%
- Hyperpigmentation
- 61.0%
- Proximal myopathy
- 60.6%
- Hypertension, with higher burden in older age groups
- 70.8%
- DM, with higher burden in older age groups
- 48.0%
Observational data: associations, not effects.
Further findings
Early biochemical remission after transsphenoidal surgery (morning cortisol < 138 nmol/L) · early postoperative
- Remission
- 166/233 (71.2%)
- Persistent disease
- 67/233 (28.8%)
- Remission, microadenomas
- 72.7%
- Remission, macroadenomas
- 72.2%
- No clear descriptive age-related pattern
Relapse after documented initial remission
- Relapse
- 22/166 (13.3%)
BMD (DXA subset)
- Reduced bone density was frequent in the clinically selected DXA subset
- 78 patients
- Not extrapolated to the entire cohort
Original publication
Clinical Profile, Biochemical Characteristics, and Surgical Outcomes in Cushing Disease: An Age‐Stratified Analysis of a Large Tertiary‐Care Cohort. Clin Endocrinol (Oxf). Published 9 August 2026. doi:10.
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