Postural stability, fall risk, and effects of balance-based exercise in acromegaly
Authors' conclusion
Balance impairment and increased fall risk may occur in acromegaly, likely due to deficits in central sensory integration.
Study context
- Population
- Patients with acromegaly (active and inactive) and matched sedentary healthy controls15 completed exercise
- Participants
- 32 vs 32
- Comparison
- Acromegaly vs matched sedentary healthy controls; before vs after balance-oriented exercise
- Acromegalyn = 32
- Controlsn = 32reference
- Outcome
- Postural stability (computerized dynamic posturography)
Methodological detailssingle-centre, exercise intervention
- Single-centre
- Exercise intervention
Main finding
As reported in the abstract
- Patients had lower preference anterior-posterior (AP), visual medial-lateral (ML), vestibular ML and global AP/ML scores than controls
- Acromegaly vs Controls: P < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Berg Balance Scale, fall risk, fear-of-falling and dizziness scores | P < 0.05 |
| Fourier analysis of sway | P < 0.05 |
| Global AP/ML scores, active vs inactive acromegalyLower in active patients | P < 0.05 |
| Vestibulo-ocular reflex gains (video head impulse test)Similar between groups | P > 0.05 |
| Effect of 8-week home-based exercise program on balance and clinical scale scores · 8 weeksAfter exercise vs Before exercise · significant improvement | P < 0.05 |
- Berg Balance Scale, fall risk, fear-of-falling and dizziness scores: Berg lower; fall risk, fear-of-falling, dizziness higher in patients
- Fourier analysis of sway: increased sway amplitudes with low-frequency dominance, static and dynamic
- Effect of 8-week home-based exercise program on balance and clinical scale scores: 15 patients with balance impairment
Original publication
Postural stability, fall risk, and effects of balance-based exercise in acromegaly. Eur J Endocrinol. Published 13 August 2026. doi:10.
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