Soluble alpha-klotho as an adjunct biomarker of disease activity in acromegaly: Added value beyond GH and IGF-1
Authors' conclusion
Soluble alpha-Klotho may serve as an adjunct marker of current biochemical activity in acromegaly, particularly for identifying uncontrolled treated or newly diagnosed active disease.
Study context
- Population
- Patients with acromegaly categorized as controlled, discordant, uncontrolled or active disease, and controls
- Participants
- 80 vs 80
- Comparison
- Acromegaly vs controls; across disease-status categories
- Acromegalyn = 80
- Controlsn = 80reference
- Outcome
- Serum soluble alpha-Klotho as adjunct biomarker of biochemical disease activity
Main finding
As reported in the abstract
Serum alpha-Klotho
P < 0.001
Observational data: associations, not effects.
Further findings
Alpha-Klotho across disease-status categories
overall P < 0.001
Identification of active/uncontrolled disease
- AUC of alpha-Klotho for active/uncontrolled disease
- 0.983
- AUC of GH, IGF-1, age, sex and BMI without alpha-Klotho
- 0.947
- AUC of GH, IGF-1, age, sex and BMI with alpha-Klotho added
- 0.986
- Alpha-Klotho correlated with GH and IGF-1
- Alpha-Klotho ≥ 1579.8 pg/mL independently associated with active/uncontrolled disease
Original publication
Soluble alpha-klotho as an adjunct biomarker of disease activity in acromegaly: Added value beyond GH and IGF-1. Pituitary. Published 20 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →