Can Growth Hormone Stimulation Tests in Children Predict the Response to Growth Hormone Treatment?
Authors' conclusion
Our findings indicate similar responses to GH treatment in children classified as GHD or ISS based on GHST. These results suggest that the pivotal role of GHST in diagnosing and treating short children should be reconsidered.
Study context
- Population
- Short, healthy children treated with growth hormone (GH), endocrine clinic at a tertiary pediatric referral center
- Participants
- Two hundred ninty-one participants
- Exposure
- Response to GH treatment in children with growth hormone deficiency (GHD) vs idiopathic short stature (ISS) based on GH stimulation testing (GHST)
- GHDn = 97
- ISSn = 194reference
- Outcome
- Response to GH treatment (height gain)
- Follow-up
- 3 years
Methodological detailssingle-centre, tertiary pediatric referral center
- Single-centre
- Tertiary pediatric referral center
Main finding
As reported in the abstract
Height gain on GH treatment
- Height significantly improved and IGF-1 levels increased independent of GHST results, gender or pubertal status
- P < .001
Observational data: associations, not effects.
Original publication
Can Growth Hormone Stimulation Tests in Children Predict the Response to Growth Hormone Treatment? Endocr Pract. Published 24 March 2025. doi:10.
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