Energy Trade-off and 4 Extreme Human Body Types
Authors' conclusion
ETOS represents a novel anthropometric trait with utility in describing body types. We discovered the multiple genomic loci and pathways probably involved in energy trade-off.
Study context
- Population
- Subjects of the GrowUp1974 Gothenburg study with growth data from ages 0.5–17.5 years; UK BioBank data for GWAS996 girls
- Participants
- 1,889 subjects
- Exposure
- Four extreme body types
- Outcome
- Height and ETOS trajectories by extreme body type
- Follow-up
- Ages 0.5-17.5 years
Methodological detailsGWAS using UK BioBank data
- GWAS using UK BioBank data
Main finding
As reported in the abstract
ages 0.5-17.5 years
- Two-hit pattern with profound changes during early infancy and at puberty for tall-slender and short-stout body types
Observational data: associations, not effects.
Further findings
GWAS of ETO-Score (ETOS)
- Several loci (including FTO, ADCY3, GDF5) and pathways highly associated with ETOS
- Most strongly associated pathways: extracellular matrix, signal transduction, chromatin organization, energy metabolism
Original publication
Energy Trade-off and 4 Extreme Human Body Types. J Clin Endocrinol Metab. Published 22 November 2022. doi:10.
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