Weekly somapacitan had no adverse effects on glucose metabolism in adults with growth hormone deficiency
Authors' conclusion
Somapacitan, compared with daily GH, did not adversely affect glucose metabolism up to 86 weeks in a large cohort of treatment-naïve or previously treated patients with AGHD.
Study context
- Population
- Adults with growth hormone (GH) deficiency (adult growth hormone deficiency (AGHD)), GH-naïve or previously treated3 RCTs
- Comparison
- Once-weekly somapacitan vs daily GH and placebo
- Outcome
- Changes from baseline in FPG, HOMA-IR and fasting insulin, GH-naïve patients
- Follow-up
- 34 and 86 weeks
Methodological detailsREAL 1, REAL 2, REAL Japan, post hoc-defined analyses, randomized controlled trials
- REAL 1, REAL 2, REAL Japan
- Post hoc-defined analyses
- Randomized controlled trials
Pooled result
As reported in the abstract
- GH-naïve (n = 120 somapacitan, n = 119 daily GH): higher changes from baseline in fasting plasma glucose (FPG), homeostasis model assessment of insulin resistance (HOMA-IR) and fasting insulin with daily GH vs somapacitan at 34 weeks, but not at 86 weeks
- HbA1c and HOMA-β did not differ between groups at either timepoint
- Post hoc-defined analyses
Further pooled results
Influence of sex, age, fasting insulin, glucose tolerance status and BMI, treatment-naïve patients
- Sex, age, fasting insulin, glucose tolerance status and BMI did not influence changes in glucose metabolism
Glucose metabolism parameters, previously treated patients
- REAL 1 extension: n = 51 somapacitan, n = 52 daily GH; REAL 2: n = 61 and n = 31; REAL Japan: n = 46 and n = 16
- Differences in changes from baseline not statistically significant between somapacitan and daily GH for any glucose metabolism parameter
Safety
- New cases of DM — Somapacitan
- 0 events
Original publication
Weekly somapacitan had no adverse effects on glucose metabolism in adults with growth hormone deficiency. Pituitary. Published 15 November 2022. doi:10.
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