Oral Levodopa Stimulates Copeptin Secretion in Children and Adolescents with Intact Posterior Pituitary Function
Authors' conclusion
Oral levodopa could be used to stimulate copeptin.
Study context
- Population
- Patients <18 years with short stature, no polyuria or polydipsia, undergoing levodopa stimulation test for suspected GHD, May 2023–Nov 2023final analysis
- Participants
- 44 patients
- Exposure
- Levodopa stimulation test vs insulin tolerance test
- Outcome
- Effect of oral levodopa on copeptin secretion
- Follow-up
- 0, 30, 60, 90 and 120 min
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
As reported in the abstract
Copeptin in the levodopa stimulation test
Copeptin at baseline, median (IQR)
5.20 (3.51, 8.25) pmol/L
Maximum copeptin, median (IQR)
19.36 (8.97, 108.08) pmol/L
P < .001
Peak vs baseline, times
3.94
1.41, 13.88P < .001
Observational data: associations, not effects.
Further findings
Peak copeptin, levodopa test vs insulin tolerance test · significantly higher with levodopa · part of patients
P = 0.009
Levodopa dose
- Higher copeptin was associated with a larger dose of levodopa
Original publication
Oral Levodopa Stimulates Copeptin Secretion in Children and Adolescents with Intact Posterior Pituitary Function. Endocr Pract. Published 24 August 2024. doi:10.
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