Diagnostic Yield of Brain MRI in Pediatric Short Stature: Hypothalamic–Pituitary Lesions and Incidental Findings in Real‐World Practice
Authors' conclusion
Among children evaluated for short stature or suspected GHD, clinically significant MRI abnormalities were uncommon and major HP pathology was rare.
Study context
- Population
- Children with short stature or suspected growth hormone deficiency (GHD) undergoing pituitary-protocol brain MRI, 2011–2024; mean age 9.2 ± 3.7 years, 60.3% boys
- Participants
- 330 children
- Outcome
- Prevalence, clinical significance and distribution of HP and extrahypothalamic MRI abnormalities
Methodological detailsreal-world, pituitary-protocol brain MRI
- Real-world
- Pituitary-protocol brain MRI
Main finding
As reported in the abstract
Clinically significant MRI abnormalities
- Clinically significant abnormalities
- 22 (6.7%)
- Major lesions
- four (1.2%)
- Hypothalamic-pituitary (HP) abnormalities
- 30 (9.1%)
- Clinically significant HP abnormalities: eight microadenomas and three large sellar masses
- 11 (3.3%)
- Non-HP abnormalities
- 41 (12.4%)
- Clinically significant non-HP abnormalities, incl. white matter changes, Chiari I malformation, subependymal heterotopia
- 11 (3.3%)
Observational data: associations, not effects.
Original publication
Diagnostic Yield of Brain MRI in Pediatric Short Stature: Hypothalamic–Pituitary Lesions and Incidental Findings in Real‐World Practice. Clin Endocrinol (Oxf). Published 10 September 2026. doi:10.
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