Brain Magnetic Resonance Imaging (MRI) Findings and Factor Associated With Clinical Significant Central Nervous System (CNS) Lesions in Girls Aged 6–8 With Central Precocious Puberty
Authors' conclusion
In girls aged 6-8 years with CPP, brain MRI abnormalities were identified in approximately 1 in 10 girls, but most were incidental or of uncertain clinical significance. Clinically significant abnormalities were enriched among girls with neurological features. Basal LH provided incremental information beyond age at diagnosis but had limited discriminatory performance. These findings support a risk-stratified approach to brain MRI in girls aged 6-8 years with CPP, with careful neurological assessment remaining central to imaging decisions.
Study context
- Population
- Girls aged 6–8 years diagnosed with central precocious puberty (CPP) who underwent brain MRI at Vietnam National Children's Hospital between April 2021 and June 2026girls aged 6–8 years diagnosed with CPP who underwent brain MRI
- Participants
- 848 participants
- Outcome
- Any brain MRI abnormalities
Main finding
As reported in the abstract
Any brain MRI abnormalities
86 girls
10.1%
Clinically significant central nervous system (CNS) lesions
30
3.5%
Questionable findings
14
1.7%
Incidental findings
42
5.0%
Observational data: associations, not effects.
Further findings
Neurological symptoms, signs or previous CNS history
- Among girls with clinically significant abnormalities
- 30.0%
- Among girls with uncertain findings
- 7.1%
- Among girls with incidental findings
- 4.8%
- p = 0.012
Clinically significant MRI abnormalities, association with basal luteinizing hormone (LH)
- Basal LH, adjusted OR per IU/L
- 1.30 (95% CI 1.14-1.47; p < 0.001)
- Independently associated
Model fit and discrimination: basal LH added to age at diagnosis
- Akaike information criterion (AIC), age at diagnosis plus basal LH vs age alone
- 247.79 vs. 259.78
- Likelihood-ratio p
- 0.0002
- AUC, age at diagnosis plus basal LH vs age alone
- 0.654 vs. 0.550
- p for AUC comparison
- 0.055
- Bone-age advancement did not provide significant additional information
- Discrimination remained modest
Original publication
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