Central Precocious Puberty in Italian Boys: Data From a Large Nationwide Cohort
Authors' conclusion
In our study on a large nationwide cohort of boys referred for precocious puberty signs, the percentage of forms associated with CNS abnormalities was one of the lowest reported in the literature.
Study context
- Population
- Otherwise normal healthy boys diagnosed with central precocious puberty (CPP) during the last 2 decades in Italy
- Participants
- 193 participants
- Exposure
- Magnetic resonance imaging (MRI)-based groups: no central nervous system (CNS) abnormalities vs mild incidental abnormalities vs causal pathological CNS abnormalities
- Outcome
- Causes of CPP and relative frequency of forms with CNS abnormalities on MRI vs idiopathic forms
Methodological detailsnational, multicenter
- National
- Multicenter
Main finding
As reported in the abstract
MRI findings
Observational data: associations, not effects.
Further findings
Chronological age at diagnosis <7 years and BMI >+2 SDS
- Higher proportion with age at diagnosis <7 years in Group 3
- P = 0.00001
- Higher proportion with BMI >+2 SDS in Group 3
- P < 0.01
GnRH analogue therapy started
- Started GnRH analogue therapy
- 183/193
Final height
- Final height in range of target height in all groups and in 9 untreated patients
Original publication
Central Precocious Puberty in Italian Boys: Data From a Large Nationwide Cohort. J Clin Endocrinol Metab. Published 3 February 2024. doi:10.
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