Natural history of pituitary incidentalomas in pediatric patients: a single-center, retrospective analysis
Authors' conclusion
Pediatric pituitary incidentalomas are generally benign. Patients did not develop endocrinopathies or neurological symptoms. In the absence of new symptoms, monitoring clinically rather than with recurrent imaging or lab evaluation may be warranted.
Study context
- Population
- Pediatric patients with a pituitary incidentaloma identified on magnetic resonance imaging (MRI) with no predisposing factors to developing brain lesions, evaluated by neurosurgery and/or endocrinology
- Participants
- 35 patients
- Outcome
- Development of endocrinopathy or new neurological symptoms
- Follow-up
- Median 23 months
Methodological detailssingle-centre, tertiary care academic children's hospital, 24 years of patients
- Single-centre
- Tertiary care academic children's hospital
- 24 years of patients
Main finding
As reported in the abstract
Endocrinopathy or new neurological symptoms
- Patients developing an endocrinopathy or new neurological symptoms
- 0
Observational data: associations, not effects.
Further findings
Lesion characteristics
- Microincidentalomas (<10 mm)
- 25
- Microincidentalomas enlarged to macroincidentalomas (≥10 mm)
- 4
- Cystic lesions
- 27
- Headache as reason for initial imaging (most common)
- 51%
Original publication
Natural history of pituitary incidentalomas in pediatric patients: a single-center, retrospective analysis. J Clin Endocrinol Metab. Published 4 February 2026. doi:10.
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