Comparison of glucagon stimulation test and low dose ACTH test in assessing hypothalamic‐pituitary‐adrenal (HPA) axis in children
Authors' conclusion
The results of this study show that GST is not an optimal tool for diagnosing secondary AI. Therefore, clinicians using this test should interpret its results with caution.
Study context
- Population
- Patients <18 years with short stature who underwent both glucagon stimulation test (GST) and LDACTH test; Pediatric Endocrinology Department, Soroka University Hospital, Beer Sheva, Israel26 excluded (>6 months between tests)
- Participants
- 120 patients
- Comparison
- GST vs LDACTH test for secondary adrenal insufficiency (AI)
- Outcome
- Diagnostic accuracy of GST cortisol cut-offs for secondary AI
Methodological detailssingle-centre
- Single-centre
Performance
As reported in the abstract
| Strategy | Sensitivity | Specificity |
|---|---|---|
| GST, cut-off 320 nmol/L | 56% | 83% |
| GST, cut-off 500 nmol/L | 100% | 6% |
Sensitivity
GST, cut-off 320 nmol/L56%
GST, cut-off 500 nmol/L100%
Specificity
GST, cut-off 320 nmol/L83%
GST, cut-off 500 nmol/L6%
Original publication
Comparison of glucagon stimulation test and low dose ACTH test in assessing hypothalamic‐pituitary‐adrenal (HPA) axis in children. Clin Endocrinol (Oxf). Published 15 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →