LMS-Based Pediatric Reference Values for Parameters of Phosphate Homeostasis in the HARP Cohort
Authors' conclusion
This is the first report of LMS-based continuous pediatric reference percentiles for key laboratory parameters of phosphate homeostasis that allow calculation of standardized patient z-scores to facilitate test result interpretation in children and adolescents.
Study context
- Population
- Children aged 0.1–18 years from outpatient hospital clinics and a secondary school program (HARP study)254 boys
- Participants
- 455 children
- Outcome
- LMS-based continuous reference percentiles for serum phosphate, plasma iFGF23, sKlotho, TmP/GFR, tubular reabsorption of phosphate (TRP), and urinary Ca/Crea and Pi/Crea ratios
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
LMS-based reference percentiles for 7 parameters of phosphate homeostasis
- Lambda-Mu-Sigma (LMS)-based percentiles and z-scores established for 7 parameters; all age-dependent
- Serum phosphate, TmP/GFR and soluble Klotho (sKlotho) associated with sex
- Serum phosphate, TmP/GFR, urinary Ca/Crea and Pi/Crea highest in infancy and declined until age 18 years
- Phosphate and TmP/GFR reached adult levels earlier in girls vs boys
- iFGF23 highest in infancy, falling to a stable plateau by 4 years of age
- sKlotho peaks during adolescence
Observational data: associations, not effects.
Original publication
LMS-Based Pediatric Reference Values for Parameters of Phosphate Homeostasis in the HARP Cohort. J Clin Endocrinol Metab. Published 18 October 2023. doi:10.
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