Longitudinal Changes in Acylated versus Unacylated Ghrelin Levels May Be Involved in the Underlying Mechanisms of the Switch in Nutritional Phases in Prader-Willi Syndrome
Authors' conclusion
The change from failure to thrive to excessive weight gain and hyperphagia in infants and children with PWS coincides with an increase in AG/UAG ratio. The increase in AG/UAG ratio occurred during phase 2a, thus before the onset of hyperphagia.
Study context
- Population
- Children with prader-Willi syndrome (PWS) and healthy controls from the Netherlands, France and Belgium
- Participants
- 134 vs 157
- Exposure
- Children with PWS vs healthy age-matched controls
- PWSn = 134
- Controlsn = 157reference
- Outcome
- Evolution of AG, UAG and the AG/UAG ratio and their association with change in eating behavior (nutritional phases)
Methodological detailshealthy age-matched controls, multinational
- Healthy age-matched controls
- Multinational
Main finding
As reported in the abstract
AG, UAG and AG/UAG ratio across age and nutritional phases
- Acylated ghrelin (AG) levels stable during nutritional phases in PWS
- p = 0.114
- Unacylated ghrelin (UAG) levels in PWS decreased from phase 1a to phase 2b
- 290 pg/mL to 137 pg/mL (p < 0.001)
- AG/UAG ratio in PWS increased significantly from phase 2a to phase 2b
- 0.81 to 1.24 (p = 0.012)
Observational data: associations, not effects.
Original publication
Longitudinal Changes in Acylated versus Unacylated Ghrelin Levels May Be Involved in the Underlying Mechanisms of the Switch in Nutritional Phases in Prader-Willi Syndrome. Horm Res Paediatr. Published 13 October 2023. doi:10.
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