Impaired Sensitivity to Thyroid Hormones Is Associated With Decreased Vitamin D Levels in the Euthyroid Population
Authors' conclusion
Impaired thyroid hormone sensitivity correlates with decreased vitamin D levels among euthyroid subjects, with associations varying by age, sex, race, and BMI.
Study context
- Population
- Euthyroid participants, National Health and Nutrition Examination Survey 2007–2012
- Participants
- 6,452 participants
- Outcome
- Association between 25(OH)D levels and thyroid hormone sensitivity indices (TFQI, TSHI, TT4RI)
Methodological detailsNHANES 2007-2012
- NHANES 2007-2012
Main finding
As reported in the abstract
25(OH)D in impaired thyroid hormone sensitivity
- Impaired thyroid hormone sensitivity associated with decreased 25(OH)D after confounder adjustment; TFQI, thyrotropin thyroxine resistance index (TT4RI)
- P < 0.05
- Impaired thyroid hormone sensitivity associated with decreased 25(OH)D after confounder adjustment; TSH index (TSHI)
- P = .05574
Observational data: associations, not effects.
Further findings
Age subgroups
- Negative correlations between sensitivity indices and 25(OH)D at 20 to 60 years, turning positive at 60 to 80 years
Sex subgroups
nmol/L
- Males: TFQI relationship shifted from negative to positive above 25(OH)D
- 63.5
- Males: TT4RI relationship shifted from negative to positive above 25(OH)D
- 56.7
- Males: TSHI relationship shifted from negative to positive above 25(OH)D
- 56.7
- Females: sensitivity indices and vitamin D negatively linked
Race subgroups
- U-shaped curvilinear patterns resembling those in males
Body mass index (BMI) subgroups
- Negative association in the <25 kg/m² and ≥30 kg/m² subgroups
- U-shaped association in the 25-30 kg/m² subgroup
Original publication
Impaired Sensitivity to Thyroid Hormones Is Associated With Decreased Vitamin D Levels in the Euthyroid Population. J Clin Endocrinol Metab. Published 13 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →