Sex‐independent timing of the onset of central puberty revealed by nocturnal luteinizing hormone concentrations
Authors' conclusion
Findings in our population with a limited sample size suggest that the timing of central pubertal activation is a sex-independent phenomenon, which can be observed by monitoring the nocturnal sleeptime total LH concentrations in urine. The lag time from central pubertal activation of gonadotropin secretion to the clinical onset of puberty is significantly longer in boys.
Study context
- Population
- Healthy volunteers followed for an average of 15 visits over 5.5 (boys) and 5.8 (girls) years on average; 24-h urine split into nocturnal sleeptime and waketime portions
- Participants
- 30 volunteers
- Exposure
- Boys vs girls
- Boysn = 17
- Girlsn = 13reference
- Outcome
- Age at which nocturnal sleeptime total urinary LH (U-LH) first reached or surpassed the 0.7 IU/L cutoff
Methodological detailsTotal urinary LH (U-LH) measured in duplicate by Delfia® IFMA (Wallac), detecting intact luteinizing hormone (LH), beta subunit and core fragment, not hCG
- Total U-LH measured in duplicate by Delfia® IFMA (Wallac), detecting intact LH, beta subunit and core fragment, not hCG
Main finding
As reported in the abstract
Mean first age of nocturnal sleeptime total U-LH ≥0.7 IU/L
P = 0.15
Observational data: associations, not effects.
Further findings
Mean time span from first nocturnal U-LH >0.7 IU/L to pubertal stage 2
Original publication
Sex‐independent timing of the onset of central puberty revealed by nocturnal luteinizing hormone concentrations. Clin Endocrinol (Oxf). Published 29 September 2023. doi:10.
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