Timing of puberty and psychiatric and somatic diseases in childhood: a population-based study
Authors' conclusion
We showed associations between ICD diagnostic codes of somatic and psychiatric diseases and the age at PHV, which is an objective method to determine the timing of puberty. Psychiatric and chronic somatic diagnoses showed contrasting associations with pubertal timing.
Study context
- Population
- Girls and boys born 1997–2002; ICD-10 diagnosis codes obtained before age 18
- Participants
- 6,347 vs 6,833
- Exposure
- Girls vs Boys
- Girlsn = 6,347
- Boysn = 6,833
- Outcome
- Association between age at peak height velocity (PHV) and ICD-10 diagnoses
- Follow-up
- Before age 18
Main finding
As reported in the abstract
Age at PHV by subsequent diagnosis (linear regression β)
- Depressive episode, girls: β (months), 95% CI −4.0 to −1.3, P < .001
- −2.7
- Depressive episode, boys: β (months), 95% CI −4.8 to −.7, P = .009
- −2.8
- Anxiety disorders, girls: β (months), 95% CI −4.0 to −1.1, P < .001
- −2.5
- Celiac disease, girls: β (months), 95% CI 4.0 to 10.7, P < .001
- 7.4
- Seronegative juvenile polyarthritis, girls: β (months), 95% CI 6.6-25.6, P = .001
- 16.1
- Acute tubulo-interstitial nephritis, boys: β (months), 95% CI 1.8-8.5, P = .003
- 5.2
- Viral pneumonia, boys: β (months), 95% CI −18.3 to −2.6, P = .009
- −10.5
- Meningitis, boys: β (months), 95% CI −30.0 to −7.8, P = .001
- −18.9
Observational data: associations, not effects.
Further findings
- Peak height velocity (PHV)-based method identified cases of precocious and delayed puberty
Original publication
Timing of puberty and psychiatric and somatic diseases in childhood: a population-based study. Eur J Endocrinol. Published 7 July 2026. doi:10.
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