From premature adrenarche to adult metabolic risk and hyperandrogenism: a systematic review and meta-analysis
Pooled result · BMI, insulin resistance and hyperandrogenismResult — go to the resultMean difference 1.4 CI 1.0–1.9Authors' conclusion
Women with a history of IPA are at increased risk of long-term insulin resistance and hyperandrogenism, with early signs of adverse cardiometabolic profiles.
Study context
- Population
- Females with idiopathic premature adrenarche (IPA) after menarche (premenarcheal adolescent and adult women); databases searched through February 202521 studies
- Participants
- 635 vs 307
- Comparison
- Idiopathic premature adrenarche vs age-matched controls
- IPAn = 635
- Controlsn = 307reference
- Outcome
- BMI, insulin resistance markers, and clinical and biochemical markers of hyperandrogenism
Methodological detailsrandom-effects models, GRADE
- Random-effects models
- GRADE
Pooled result
BMI, insulin resistance and hyperandrogenism
Mean difference
1.4
CI 1.0–1.9
IPAvs Controls
mean difference 1.4 (CI 1.0–1.9)
As reported in the abstract
Further pooled results
Cardiometabolic markers
- Higher TG, lower HDL, increased leptin and greater carotid intima-media thickness with IPA
Original publication
From premature adrenarche to adult metabolic risk and hyperandrogenism: a systematic review and meta-analysis. J Clin Endocrinol Metab. Published 30 June 2026. doi:10.
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