Finding Early Biomarkers to Prevent Unfavorable Long-Term Health Outcomes after Premature Adrenarche: A Multicenter Prospective Cohort Study Protocol
Study context
- Population
- Children with premature adrenarche (PA) and age-matched healthy controls, followed from adrenarche through puberty into early adulthood; 2 centres (Kuopio, Finland; Bern, Switzerland)
- Planned comparison
- PA vs age-matched healthy controls
Methodological detailsmulticenter, longitudinal, age-matched healthy controls, multi-omics profiling, in vitro adrenal cell model validation, Phenotypic assessments incl. medical histories and body composition analyses; multi-omics (transcriptomics, metabolomics) by liquid and gas chromatography tandem-mass spectrometry and RNA sequencing
- Multicenter
- Longitudinal
- Age-matched healthy controls
- Multi-omics profiling
- In vitro adrenal cell model validation
- Phenotypic assessments incl. medical histories and body composition analyses; multi-omics (transcriptomics, metabolomics) by liquid and gas chromatography tandem-mass spectrometry and RNA sequencing
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Finding Early Biomarkers to Prevent Unfavorable Long-Term Health Outcomes after Premature Adrenarche: A Multicenter Prospective Cohort Study Protocol. Horm Res Paediatr. Published 29 July 2025. doi:10.
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