Central Precocious Puberty in Males, GnRH Analog Treated or Untreated, Did Not Impact Fertility and Health in Midadulthood
An erratum to this article was published (J Clin Endocrinol Metab, 18 Nov 2025 ↗)
Authors' conclusion
A history of ICPP in males, whether treated or untreated, does not appear to be associated with adverse long-term outcomes in reproductive, metabolic, emotional, or oncological health. Overall, adult men with prior ICPP exhibit similar health profiles to those of the general population.
Study context
- Population
- Men aged 29 to 48 years with a history of idiopathic central precocious puberty (ICPP); Clalit Health Services database118 ICPP, 351 matched controls
- Participants
- 68 / 50 / 204 / 147
- Exposure
- GnRH analog treated vs untreated ICPP, and each vs matched controls
- Treatedn = 68
- Untreatedn = 50reference
- Controls (treated)n = 204
- Controls (untreated)n = 147
- Outcome
- Prevalence of reproductive issues, metabolic conditions (obesity, hypertension, hyperlipidemia, diabetes), osteoporosis, malignancy, and psychopathology
Methodological detailsage, birth year and socioeconomic status-matched controls
- Age, birth year and socioeconomic status-matched controls
Main finding
As reported in the abstract
Prevalence of outcomes, treated vs untreated ICPP
- No significant differences between treated and untreated groups
- Treated vs Untreated: P = 0.317
- Treated vs Untreated: P = 0.946
- Treated vs Untreated: P = 0.780
- Treated vs Untreated: P = 0.931
- Treated vs Untreated: P = 0.698
- Treated vs Untreated: P = 0.160
Observational data: associations, not effects.
Further findings
Median age
P < 0.001
ICPP vs respective matched controls
- Reproductive and health outcomes comparable between ICPP patients and their respective controls, regardless of treatment history
Original publication
Central Precocious Puberty in Males, GnRH Analog Treated or Untreated, Did Not Impact Fertility and Health in Midadulthood. J Clin Endocrinol Metab. Published 28 July 2025. doi:10.
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