A Growth Prediction Model from Mid-Puberty to Near Adult Height in Adolescents with Idiopathic Isolated Growth Hormone Deficiency Treated with Growth Hormone
Authors' conclusion
For females, explained variance was insufficient to reliably predict height gain. For GH sufficient males, the model can be used to assess efficacy of continuing or discontinuing rhGH treatment at mid-puberty in future studies.
Study context
- Population
- Adolescents with idiopathic isolated GH deficiency (idiopathic isolated growth hormone deficiency (IIGHD)) treated with recombinant human growth hormone (rhGH) until near adult height (NAH), Dutch National Registry of Growth Hormone Treatment in Childrenvalidation: 33 males, 7 females
- Participants
- 151 adolescents
- Comparison
- Males vs Females
- Outcome
- Height gain from mid-puberty to NAH
Methodological detailsregistry-based, Predictors: age, bone age, Tanner stage, target height SDS minus height SDS at mid-puberty
- Registry-based
- Predictors: age, bone age, Tanner stage, target height SDS minus height SDS at mid-puberty
Performance
As reported in the abstract
Variance in height gain explained by the model
| Test or model | Value | Residual SD |
|---|---|---|
| Males | 48% | 4.16 cm |
| Females | 18% | 3.64 cm |
Value
Males48%
Females18%
Residual SD
Males4.16 cm
Females3.64 cm
Further findings
Validation: difference between predicted and attained NAH (GH-sufficient at mid-puberty, continued rhGH)
Original publication
A Growth Prediction Model from Mid-Puberty to Near Adult Height in Adolescents with Idiopathic Isolated Growth Hormone Deficiency Treated with Growth Hormone. Horm Res Paediatr. Published 18 July 2025. doi:10.
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